Structural insight into substrate specificity of phosphodiesterase 10
نویسندگان
چکیده
منابع مشابه
Structural insight into substrate specificity of phosphodiesterase 10.
Phosphodiesterases (PDEs) hydrolyze the second messengers cAMP and cGMP. It remains unknown how individual PDE families selectively recognize cAMP and cGMP. This work reports structural studies on substrate specificity. The crystal structures of the catalytic domains of the D674A and D564N mutants of PDE10A2 in complex with cAMP and cGMP reveal that two substrates bind to the active site with t...
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[This corrects the article DOI: 10.1371/journal.pone.0152611.].
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0700279104